2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. LIM Kinase (LIMK)

LIM Kinase (LIMK)

(LIMK)

LIMKs

LIM Kinase (LIMK)

Related Products

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LIM kinases (LIMKs) are important cell cytoskeleton regulators that play a prominent role in cancer manifestation and neuronal diseases. The LIMK family consists of two homologues, LIMK1 and LIMK2, which differ from one another in expression profile, intercellular localization, and function. The main substrate of LIMK is cofilin, a member of the actin-depolymerizing factor (ADF) protein family. When phosphorylated by LIMK, cofilin is inactive. LIMKs play a contributory role in several neurodevelopmental disorders and in cancer growth and metastasis.

LIM domain kinases (LIMK1 and 2) are substrate for Cdc42/Rac-PAK, and modulate actin dynamics by phosphorylating cofilin at serine-3. This modification inactivates cofilin’s actin severing and depolymerizing activity. LIMKs also translocate into the nucleus and regulate cell cycle progression. LIMKs are potential therapeutic targets for NF2 and other merlin-deficient tumors.

LIM Kinase (LIMK) Isoform Specific Products:

LIM Kinase (LIMK) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P5455
    S3 Fragment
    		Inhibitor
    S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)
    S3 Fragment
  • HY-N10868
    8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide
    		Inhibitor
    8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, has anti-LIMK1 activity. 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide has inhibitory property on cell motility.
    8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide
  • HY-RS07663
    Limk1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Limk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Limk1 Mouse Pre-designed siRNA Set A
    Limk1 Mouse Pre-designed siRNA Set A
  • HY-RS07667
    Limk2 Rat Pre-designed siRNA Set A
    		Inhibitor

    Limk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Limk2 Rat Pre-designed siRNA Set A
    Limk2 Rat Pre-designed siRNA Set A
  • HY-RS07666
    Limk2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Limk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Limk2 Mouse Pre-designed siRNA Set A
    Limk2 Mouse Pre-designed siRNA Set A
  • HY-135843
    TH-263
    		Control ≥99.0%
    TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257.
    TH-263
  • HY-123345
    CRT 0105446
    		Inhibitor
    CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC50 of 8 nM.
    CRT 0105446
  • HY-N8669
    Curcolonol
    		Inhibitor
    Curcolonol is a furan type sesquiterpene. Curcolonol can be isolated from several medical herbs. Curcolonol has inhibitory activity for LIM kinase 1. Curcolonol can be used for the research of breast cancer.
    Curcolonol
  • HY-RS07665
    LIMK2 Human Pre-designed siRNA Set A
    		Inhibitor

    LIMK2 Human Pre-designed siRNA Set A contains three designed siRNAs for LIMK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    LIMK2 Human Pre-designed siRNA Set A
    LIMK2 Human Pre-designed siRNA Set A
  • HY-161417
    LIMK-IN-2
    		Inhibitor
    LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity.
    LIMK-IN-2
  • HY-144438
    Aurora/LIM kinase-IN-1
    		Inhibitor
    Aurora/LIM kinase-IN-1 (Compound F114) is a potent and dual inhibitor of aurora and lim kinase. Aurora kinases and lim kinases are involved in neoplastic cell division and cell motility, respectively. Aurora/LIM kinase-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM kinase-IN-1 is a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future agent development efforts for GBM, and potentially other cancers.
    Aurora/LIM kinase-IN-1
  • HY-RS07664
    Limk1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Limk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Limk1 Rat Pre-designed siRNA Set A
    Limk1 Rat Pre-designed siRNA Set A
  • HY-RS07662
    LIMK1 Human Pre-designed siRNA Set A
    		Inhibitor

    LIMK1 Human Pre-designed siRNA Set A contains three designed siRNAs for LIMK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    LIMK1 Human Pre-designed siRNA Set A
    LIMK1 Human Pre-designed siRNA Set A
  • HY-14226
    LIMK-IN-3
    		Inhibitor
    LIMK-IN-3 (Compound 33) is a LIMK2 inhibitor (IC50: 1.2 nM). LIMK-IN-3 can be used for glaucoma research.
    LIMK-IN-3
  • HY-168908
    LIJTF500025
    		Inhibitor
    LIJTF500025 is a potent and selective LIMK inhibitor, with pIC50 values of 6.77 and 7.03 for LIMK1 and LIMK2, respectively, as determined by NanoBRET. LIJTF500025 can be used for the research of cancer.
    LIJTF500025
  • HY-W070753
    LIMK1 inhibitor 2
    		Inhibitor
    LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with the IC50 of 9 μM.
    LIMK1 inhibitor 2
  • HY-12659B
    LX7101 monohydrochloride
    		Inhibitor
    LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research.
    LX7101 monohydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
LIM Kinase (LIMK) Isoform Comparison

LIMK1

LIMK2

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

LIM Kinase (LIMK) Degraders & Inhibitors
Product NameLIMK1LIMK2Purity    
SM1-71
LIMK1
 
BMS-5
LIMK1, IC50: 7 nM
LIMK2, IC50: 8 nM
99.51%
BMS-3
LIMK1, IC50: 5 nM
LIMK2, IC50: 6 nM
99.71%
TH-257
LIMK1, IC50: 84 nM
LIMK2, IC50: 39 nM
98.36%
LIMK1 inhibitor 1
LIMK1
 
SR7826
LIMK1, IC50: 43 nM
 99.30%
T56-LIMKi 
LIMK2
98.67%
DB0614 
LIMK2
98.80%
CRT0105950
LIMK1, IC50: 0.3 nM
LIMK2, IC50: 1 nM
99.91%
DD-03-156 
LIMK2
99.63%
DB1113
LIMK1
 99.28%
TH470
LIMK1, IC50: 9.8 nM
LIMK2, IC50: 13 nM
99.57%
R-10015
human LIMK1, IC50: 38 nM
 99.72%
LIMK-IN-1
LIMK1, IC50: 0.9 nM
LIMK2, IC50: 0.5 nM
99.33%
LIMK1 inhibitor BMS-4
LIMK1, pIC50: 7.25
LIMK2, pIC50: 6.87
≥99.0%
8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide
LIMK1
 
LIMK-IN-3 
LIMK2, IC50: 1.2 nM
LX7101 monohydrochloride
LIMK1, IC50: 24 nM
LIMK2, IC50: 1.6 nM